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No. Neither has been shown to be unsafe for human consumption.
Saccharin has been used for over 100 years with no apparent adverse effects, and it is considered to be a safe food ingredient.
Aspartame was extensively tested before it was approved as a food additive by the Food and Drug Administration in 1981.
As with any food or food ingredient, if you have an unpleasant reaction after consuming a sugar substitute, you can choose not to use it.
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