Yes. There are two reasons this could happen. The part of the rose that now has a different-colored flower and different-sized leaves could be a genetic sport. This genetic mutation can be spontaneous, and sports have resulted in many of our new plant cultivars.
The most likely cause, however, is that the original rose was grafted. The original rose died back to the graft and it has been replaced by the root stock rose. Sometimes a sucker from the root stock will appear among the stems of the desired rose. Check to see where the new rose is coming from. If it's from below the graft, you have your answer. You could cut off the offending rose if it is just one stem, or replace the complete bush if the graft has died. Try to select roses that are not grafted and are hardy for your area.
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