Early studies with few animal numbers have shown that prostaglandin and similar hormone-like substances can be used for synchronization in cycling females. Studies have shown that during the breeding season, prostaglandin administered at a dose of five to 125 milligrams (mg), given 11 to 14 days apart has been effective in synchronizing estrus. Two injections (1.5 to 3 cc) given 11 days apart is the common protocol. The second injection ensures an increased chance of lysing the corpus luteum to allow the doe to return to estrus. Higher doses of prostaglandin use (> 250mg) have been implicated in lowering conception rates even though estrus is displayed. The most commonly used prostaglandin is dinoprost tromethamine, commercially available as Lutalyse (Pharmacia and Upjohn Co.,Kalamazoo, MI).
Only effective during the breeding season, prostaglandin use, in combination with the male effect, may also offer a flexible, economical method for synchronization to shorten the breeding season in a natural mating situation. In addition, prostaglandin has been used as a co-treatment in effective progestogen-based synchronization protocols in goats for natural mating, artificial insemination and timed artificial insemination situations.
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Keywords: Prostaglandin, estrus synchronization, corpus luteum, economical
References: Whitley, N.C. and D. J. Jackson. 2004. An update on estrus synchronization in goats: a minor species. J. Anim. Sci. 82: E270-276E (Proceedings).