Cattle vaccines, such as lepto and clostridial, are killed, non-infectious products with duration of immunity lasting only six to 12 months. This means that boosters are required every 12 months for the prevention of occurrences and every six months to control an outbreak. However, the initial vaccination requirements of these killed vaccines is two doses, three to six weeks apart. The protective immunity that is desired develops two to four weeks following the second booster. This vaccination regimen is also used for killed and chemically altered (CattleMaster) non-infectious respiratory vaccines. Modified live respiratory vaccines that are infectious provide duration of immunity longer than 12 months in cattle. Recommendations may be boosters every one to three years or no boosters, depending on the lifetime immunity of the vaccine. Veterinarians’ recommendations for boosters of modified vaccines are based on products and risks of exposure.
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